CORDIS Project
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This project investigates how changes in the urea cycle contribute to cancer progression by altering nitrogen metabolism. It aims to identify specific biomarkers and therapeutic targets that can improve cancer diagnosis and treatment outcomes.
Almost 100 years ago, Warburg described a metabolic change in energy flux that occurs during carcinogenesis.
Since then, multiple studies have demonstrated how anabolic synthesis of macromolecules can be altered to support cancer cell progression.
Yet, the potential effect of altered catabolic degradation of macromolecules on tumour carcinogenesis has been much less studied.
The urea cycle (UC) is the main catabolic pathway by which mammals excrete waste nitrogen.
Although the complete UC pathwa…
WEIZMANN INSTITUTE OF SCIENCE
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