CORDIS Project
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This project investigates the role of metabolites in regulating E3 ligases, which are crucial for cellular processes. By developing new tools to monitor these ligases, the research aims to uncover insights into their activity and potential therapeutic applications for diseases like cancer.
The ubiquitin system, a central regulator of cellular processes, relies on the activity of approximately 650 E3 ligases to mediate the ubiquitination of cellular entities.
This activity is tightly regulated to avoid aberrant ubiquitination, a hallmark of numerous diseases.
While several regulatory layers of ligase activity have been documented, a novel factor – activity control by metabolites – remains vastly underexplored. A key bottleneck for uncovering metabolite-driven regulation has been th…
UNIVERSITY OF DUNDEE
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