CORDIS Project
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This project investigates the role of regulatory T-cells in immune responses, particularly during cancer therapy. It focuses on how the epidermal growth factor receptor influences these cells' functionality, aiming to enhance the effectiveness of adoptive cell transfer therapies.
FoxP3 expressing regulatory T-cells play an important role in the induction of peripheral tolerance and the prevention of auto-immune responses.
How the functionality of regulatory T-cells is regulated at the site of inflammation remains poorly understood.
We just recently discovered that the functionality of regulatory T-cells is regulated via the EGF-R that is expressed by activated regulatory T-cells.
In in vitro suppression assays the presence of the EGF-like growth factor Amphiregulin signi…
THE UNIVERSITY OF EDINBURGH
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