CORDIS Project
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This project investigates the structural mechanisms of ubiquitination, focusing on the human E3 ligase HACE1. By employing advanced techniques like cryo-electron microscopy, it aims to elucidate how HACE1 modifies substrates, which is crucial for understanding its role in diseases.
Ubiquitination is a pivotal regulator of eukaryotic protein functions, governing myriad cellular pathways.
Its deregulation causes manifold human diseases, yet our incomplete understanding of the underlying structural mechanisms has limited therapeutic efforts.
Within the ubiquitination machinery, ubiquitin ligases (E3s) present major specificity determinants, as they select substrates for modification and decorate them with ubiquitin signals.
These signals frequently comprise ubiquitin chains o…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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