CORDIS Project
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This project investigates cerebral cavernous malformations, focusing on a specific type of endothelial cell that may contribute to the disease. By exploring the characteristics and behavior of these cells, the research aims to identify potential therapeutic targets for treatment.
Cerebral cavernous malformations (CCM) is a disease characterized by focal capillary-venous cavernomas located in the central nervous system.
These malformations are fragile and bleed leading to seizures, paralysis and cerebral hemorrhages.
The familial form of CCM is due to loss of function mutations of anyone of three genes called Ccm1, Ccm 2 and Ccm 3.
Open skull surgery is the only possible therapy since effective medical treatments are still missing.
In mouse models of CCM and human patient…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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