CORDIS Project
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This project investigates the relationship between the gut microbiome and cancer immunity to enhance personalized cancer vaccines and immunotherapy. By exploring how microbiome influences T cell responses to tumors, it aims to improve treatment efficacy and develop new prognostic tools.
This proposal intends to shed light on the interplay between cancer immunity and gut microbiome as a way to optimize personalized cancer vaccines and immunotherapy.
The project originates from two milestone discoveries.
First, to be effective cancer immunotherapies have to target CD4+/CD8+ T cell neo-epitopes, which originate from tumor mutations.
Second, the gut microbiome influences the effectiveness of anti-PD-1/PD-L1 antibody immunotherapy both in animal models and in humans.
We also recentl…
UNIVERSITA DEGLI STUDI DI TRENTO
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