CORDIS Project
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This project investigates the use of splicing-modifying antisense oligonucleotides as a potential therapy for lung adenocarcinoma. By targeting alternative splicing mechanisms, the project aims to inhibit tumor growth in preclinical models, including patient-derived tumors in mice, and explore combinations with existin…
Here we propose to test the therapeutic potential of a novel class of reagents, known as splicing-modifying antisense oligonucleotides, in preclinical models of lung adenocarcinoma, including patient-derived tumours in mice.
Alternative splicing is a major mechanism of gene regulation by which different messenger RNAs and proteins are generated from a single gene, often displaying distinct, even antagonistic functions.
Alterations in alternative splicing have been linked with a plethora of patho…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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