CORDIS Project
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This project investigates the structure and dynamics of voltage-dependent anion channels, specifically VDAC2, in the mitochondrial outer membrane. It aims to understand how VDAC2 interacts with apoptotic proteins, potentially influencing apoptosis and neurodegeneration using solid-state nuclear magnetic resonance and m…
Voltage-dependent anion channels (VDACs) are pore-forming proteins expressed in the outer membrane of eukaryotic mitochondria.
The three isoforms of VDAC, i.e., VDAC1, VDAC2 and VDAC3, are known to be expressed ubiquitously in mammalian mitochondria.
The individual VDAC isoforms (VDAC1 and VDAC2) are considered to play different roles in the induction of apoptosis through Bcl-2 family proteins and may also play a role in switching apoptotic signaling, whereas the function of VDAC3 is till date n…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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