CORDIS Project
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This research examines the mechanisms of neurotransmitter refilling in neurons, focusing on the roles of proton and chloride gradients. By using advanced imaging techniques, it aims to uncover how these gradients influence synaptic transmission and vesicle dynamics.
In newly endocytosed synaptic vesicles, a proton electrochemical gradient is produced by the vacuolar-type H+-ATPase in order to power transport processes across the membrane.
The mechanisms responsible for vesicle refilling have been largely investigated on isolated synaptic vesicles.
Biochemical investigation indicates that the preference of vesicle filling for each component of the electrochemical gradient, namely the membrane potential and the proton gradient, depends on the specific transpo…
Westfälische Wilhelms-Universität Münster
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