CORDIS Project
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This project explores the mechanisms of neurotransmitter release and retrieval in neurons, focusing on the dynamics of synaptic vesicle cycling. By using advanced imaging techniques, it aims to uncover the relationship between vesicle fusion and endocytosis.
Neurotransmitters are released by exocytosis of synaptic vesicles at the presynaptic terminal.
After exocytosis, vesicular components are retrieved by endocytosis for maintaining efficient synaptic transmission.
The mechanism of vesicle fusion and retrieval has been subjected to intense interest but also fierce debate for the last 40 years.
Several modes of synaptic vesicle cycling have been described that rely on distinct kinetics, associated proteins and spatial organisation of the exo- and en…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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