CORDIS Project
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This project investigates the molecular mechanisms of vesicle tethering at the Golgi apparatus, focusing on protein interactions and the roles of various proteins involved in sorting. By utilizing biochemical and genetic methods, the research aims to identify unknown factors and enhance understanding of glycan synthesi…
The correct sorting of proteins is an important challenge for all eukaryotic cells.
Problems in protein sorting are known to lead to various developmental defects or acquired diseases in humans.
In the secretory pathway, whose main sorting hub is the Golgi apparatus, vesicular transport is used to sort proteins.
To maintain the unique composition of different Golgi cisternae for example, resident Golgi-enzymes are continuously sorted away from their substrates, the secreted proteins.
This is mos…
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