CORDIS Project
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This project seeks to develop a comprehensive model of HIV maturation by examining the interactions of viral components at the molecular level. It aims to understand how these interactions influence the virus's lifecycle and resistance to treatments.
Viral morphogenesis, the phenomenon by which viruses reorganize their internal macromolecular structure in space and time across their lifecycle, is a complex process that is not quantitatively understood.
HIV maturation, in particular, involves detailed atomistic processes such as protein-ligand recognition and cleavage that triggers large-scale macromolecular spatiotemporal rearrangement such as capsid self-assembly and RNA-modulated nucleocapsid condensation leading to infectious virus partic…
FREIE UNIVERSITAET BERLIN
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