CORDIS Project
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This project explores the role of MAVS, a key protein in the immune response, in antiviral signaling. It aims to understand how MAVS localization in different cellular organelles influences the body's defense mechanisms against viral infections.
Viruses are of great importance for global public health.
The first line of cellular defenses against viral infection begins with the binding of viral RNA to intracellular pathogen recognition receptors.
Such interaction triggers the conformational change of these receptors and allows subsequent interaction with the adaptor molecule MAVS.
Once activated, MAVS recruits a signaling complex able to activate transcription factors that induce the direct expression of ‘early IFN stimulated genes’ (ISG…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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