CORDIS Project
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This project investigates how the immune system tolerates the semi-allogenic fetus during pregnancy. By examining regulatory T cells at the maternal-fetal interface, it seeks to uncover mechanisms that could inform treatments for conditions like recurrent miscarriage and organ transplantation.
The presence of foreign (allogenic) tissue in a host yields an immune response with the goal to destroy the tissue.
During pregnancy, however, the semiallogenic fetus is allowed to grow within the maternal uterus.
This ‘immunological paradox of pregnancy’ has received much attention because of its therapeutic implications in organ transplantation and autoimmune diseases.While it has recently been established that regulatory T cells are essential in establishing tolerogenic conditions during preg…
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
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