CORDIS Project
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This project explores the structure and function of molecular machines in bacteria that transport substances, including antibiotics and toxins. It aims to understand how these pumps operate and are regulated, with implications for addressing drug resistance in pathogenic strains.
The project will investigate multi-component molecular machines that drive substrates across the cell envelope of bacteria.
Some of the machines pump antibiotics or toxins, and so contribute to drug resistance and virulence in pathogenic strains.
Questions that will be addressed include what the molecular pumps look like, how they are assembled and regulated, how they capture and translocate substrates, and the stereochemical basis for the cooperative switching of substrate-binding states.
Molec…
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