CORDIS Project
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This project aims to enhance the safety of live-attenuated vaccines for mosquito-borne viruses by preventing their replication in mosquito vectors. It utilizes a small RNA-based mechanism to target and degrade viral RNA, focusing on significant human diseases like dengue, Zika, and chikungunya.
Live-attenuated viral vaccines are among the most successful vaccine approaches and have been used for decades.
However, live-attenuated vaccines come with a risk of reversion or recombination of the vaccine to a virulent form.
An important consideration for live-attenuated vaccines for arthropod-borne (arbo-) viruses is that they should not replicate in their mosquito vectors to prevent unwanted spread of the vaccine and vaccine-derived virulent strains.
In this ERC Proof-of-Concept project (VI…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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STICHTING RADBOUD UNIVERSITEIT
Netherlands, Nijmegen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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