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VIVASEQ focuses on the mechanisms behind the sequestration of Trypanosoma vivax, a parasite causing significant livestock disease. The project aims to identify adhesion factors and metabolic processes that facilitate this interaction, with the goal of developing strategies to disrupt the disease.
Animal African trypanosomiasis (AAT) is a deadly vector-borne disease of livestock caused by Trypanosoma brucei, T. congolense, and T. vivax. T. vivax is the least studied but the most geographically widespread, driving epidemics across Africa and South America with major economic and social impacts.
In the mammalian host, T. vivax exhibits unique vascular tropism through cytoadhesion to endothelial cells (i.e. sequestration), which promotes endothelial activation and tissue pathology.
This host…
UNIVERSIDADE CATOLICA PORTUGUESA
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