CORDIS Project
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This project focuses on the role of the VRN1 protein in maintaining gene silencing in plants, particularly during the cold-induced process of vernalization. It aims to establish a mechanistic understanding of how this process works at the molecular level.
Modifications of a cells chromatin landscape enable cells to memorize and maintain gene expression profiles throughout many cell-cycles during development.
In animals and plants the Polycomb Repressive Complex 2 (PRC2) is involved in maintaining genes in an epigenetic “off” state.
In mammals and flies a second complex, PRC1, collaborates with PRC2 to maintain silencing.
Interestingly, other organisms including worms and plants lack PRC1 and it remains elusive how they achieve stable silencing. I…
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