CORDIS Project
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This project explores how Trypanosoma brucei, a parasite, uses antigenic variation to evade the immune system. By investigating the spatial organization of its Variant Surface Glycoprotein genes, the research aims to uncover the mechanisms behind antigen switching and improve understanding of parasite behavior.
Pathogens use antigenic variation to evade host antibodies and cause diseases in humans.
Interestingly, in many species antigen switching occurs non-randomly in a hierarchical manner, with specific antigen genes selected in succession.
Trypanosoma brucei is a key model organism for the study of antigenic variation in which antigen switching hierarchies of its Variant Surface Glycoprotein (VSG) genes operate.
However, how exactly this hierarchy is determined is unknown.
Studies in T. brucei have…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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