CORDIS Project
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This project investigates the role of septal GABAergic neurons in cognitive functions such as memory and spatial navigation. It aims to understand how degeneration in these neurons affects brain networks and identify potential biomarkers for related disorders.
Septal GABAergic projection neurons are considered “pacemaker” cells as they enable the temporal organization of neuronal spike firing in hippocampal and entorhinal networks that support spatial- and object-coding.
Accordingly, medial septum inactivation is associated with cognitive impairments, but the specific role of the septal-entorhinal GABAergic projections therein has remained unexplored.
This is a pressing question, as we have evidence that septal GABAergic projections exhibit enhanced v…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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