CORDIS Project
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This project focuses on developing new synthetic analogs of vinca alkaloids, crucial for cancer treatment. By using innovative organic synthesis and modeling techniques, the aim is to create structurally diverse compounds that can improve drug efficacy and combat resistance in cancer therapy.
Small natural molecules represent an irreplaceable tool in the search for new agents and new directions in medicinal chemistry.
In the cancer treatment area, the 79.8% of the new chemical entities approved for drug use from 1981 to 2006 were registered as naturally derived or inspired.
The organic synthesis of natural product analogs of varying degrees of structural complexity is a powerful way of providing new drugs, improving ADME (Absorption, Distribution, Metabolism, Excretion) properties, f…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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