CORDIS Project
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The project aims to explore the role of a specific protein complex in ovarian cancer progression and chemotherapy resistance. By targeting this complex, the research seeks to develop new therapeutic strategies to improve treatment outcomes for patients.
Ovarian Cancer (OC) is the most lethal gynecological tumor and has an especially high impact in Europe. 70% of patients develop an advanced stage due to the lack of early diagnosis tools and chemotherapy resistance.
Therefore, a better understanding of altered molecular mechanisms driving OC progression is needed.
Preliminary data from the host lab suggest that a complex formed by R2TP/TTT/WAC upon glucose and glutamine depletion, impairs mTOR activation.
Moreover, the components of this complex…
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