CORDIS Project
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The WATs-UP project investigates how obesity affects lipid uptake in white adipose tissue and its impact on vascular health and cardiovascular disease. Using advanced mouse models and human cell systems, it aims to uncover the mechanisms linking obesity-related changes in fat metabolism to vascular dysfunction and athe…
Obesity is associated with adipose tissue dysfunction and greatly increased risk for developing not only metabolic pathologies but also cardiovascular disease (CVD).
While insulin resistance and adipose-derived cytokines are established drivers of vascular dysfunction and atherosclerosis initiation, the direct contribution of changes in white adipose tissue (WAT) lipid uptake on vascular health has remained unresolved, yet would open up novel treatment opportunities.
My lab has built an arsenal…
KAROLINSKA INSTITUTET
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