CORDIS Project
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This project investigates the role of neuroligins and neurexins in synapse formation and function, particularly in relation to autism spectrum disorders. Using various genetic and biochemical techniques, it aims to uncover how these proteins interact and contribute to synaptic signaling in the brain.
The proper coupling between presynaptic and postsynaptic neurons is essential for synaptic signalling.
Synapse formation, maturation, and maintenance are controlled by cell adhesion systems that recruit and organise the synaptic protein machinery.
One such system comprises presynaptic neurexins and postsynaptic neuroligins.
Of the five known neuroligins, neuroligin 1 is specific for excitatory synapses, while neuroligin 2 is specific for inhibitory synapses and Neuroligin 3 is found on both exci…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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