CORDIS Project
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This project investigates the role of the Adenomatous Polyposis Coli gene in colorectal cancer using a Drosophila model. By studying the genetic pathways involved, the research aims to uncover mechanisms of malignant transformation in the intestinal epithelium.
The intestinal epithelium is a highly self-renewing tissue, which is replenished by multipotent stem cells.
Deregulation of normal intestinal homeostasis often results in malignant transformation.
Colorectal carcinoma is one of the most common cancers in western world.
Inactivating mutations of the Apc (Adenomatous Polyposis Coli) gene is key for colorectal cancer; up to 80% of sporadic colorectal cancers have Apc mutations.
The main tumour suppressive function of Apc is to negatively regulate W…
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