CORDIS Project
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This project focuses on understanding the molecular mechanisms of Wnt signaling, which is crucial for stem cell maintenance and cancer development. By investigating receptor dynamics and interactions, the research aims to identify potential therapeutic targets for regenerative medicine and cancer treatment.
Wnts are a family of secreted glycoproteins that control maintenance and proliferation of stem cell reservoirs during tissue homeostasis and regeneration after injury.
Deregulated Wnt signalling due to mutations in important signalling intermediates is strongly linked to disease.
The complex molecular mechanisms mediating Wnt-induced cell responses are therefore of wide interest and the underlying protein interactions provide attractive drug targets, particularly in regenerative medicine and can…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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