CORDIS Project
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This project investigates how the spatial organization of genes within the nucleus changes during cell differentiation and stress responses in C. elegans. It aims to uncover the mechanisms behind these chromatin movements and their functional significance.
During development and cellular differentiation, cells acquire specific fates by regulating spatially and temporally the expression of certain groups of genes.
This correlates with drastic changes in the 3D organization of the genome. A recent discovery from the Gasser lab has demonstrated that in differentiated cells of C. elegans, tissue-specific promoters relocate inward the 3D nuclear space when activated, and maintain this subnuclear position in a tissue-specific manner into adulthood.
Anot…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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