CORDIS Project
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This project explores the relationship between endoplasmic reticulum stress and inflammation in intestinal epithelial cells, particularly its connection to inflammatory bowel disease and colorectal cancer. It aims to identify molecular pathways that could lead to new therapeutic strategies for these conditions.
Endoplasmic reticulum (ER) stress allows cells to cope with misfolded proteins through the Unfolded Protein Response (UPR).
We have recently reported that unabated ER stress, a consequence of genetic deletion of X-box binding protein-1 (XBP1), in intestinal epithelial cells (IECs) leads to intestinal inflammation reminiscent of inflammatory bowel disease (IBD), and polymorphisms in XBP1 were associated with Crohn s disease and ulcerative colitis.The current proposal is based on this central disc…
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