CORDIS Project
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This project aims to model the X chromosome inactivation process in human cells to understand its regulation and implications for female development and disease susceptibility. By utilizing human embryonic stem cells, the research will explore the phases of X chromosome inactivation and identify key mechanisms involved…
The X chromosome is subjected to a formidable degree of concerted gene regulation, with appropriate dosage of X-linked expression in female mammals being ensured by the stable yet reversible inactivation of one of the two copies.
The process of X chromosome inactivation (XCI) is critical for female development and linked to sex-specific traits and susceptibilities to various diseases.
Well characterized in rodents, there is remarkably little knowledge of how XCI is articulated and controlled in…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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