CORDIS Project
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This project utilizes CRISPR/Cas9 technology to develop a novel animal model for studying congenital anomalies of the kidney and urinary tract in the amphibian Xenopus tropicalis. It aims to identify genetic causes of kidney diseases and potential therapeutic targets to improve clinical outcomes.
CRISPR/Cas9 has untapped potential for disease modeling in the diploid amphibian model organism Xenopus tropicalis (X. tropicalis).
Here, I propose to employ state-of-the-art CRISPR/Cas9 technologies (in vivo CRISPR Screening, ShCAST, CRISPR-NSID) to address two current unmet clinical needs in congenital anomalies of the kidney and urinary tract (CAKUT).
First, I will generate a novel animal model for autosomal dominant polycystic kidney disease (ADPKD) and investigate the role of a potential n…
UNIVERSITAT ZURICH
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