CORDIS Project
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This project investigates how human microglia contribute to neuronal toxicity in Alzheimer's disease by exploring their interactions with synapses and the release of inflammatory factors. Using a human microglia model, it aims to clarify the mechanisms of microglial activation and their role in neurodegeneration.
The goal of this project is to decipher the exact cellular and molecular mechanisms by which human microglia transduce toxicity to neurons in Alzheimer's disease (AD).
Genetics revealed that microglia are one of the central players in the pathogenesis of AD. I and others have characterized the phenotypic response of microglia in AD using transcriptomic and epigenetic tools.
Nevertheless, it is yet to be defined how microglia communicate with other cells in the brain, by which mechanism they lead…
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