CORDIS Project
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This project investigates the mechanisms of DNA interstrand crosslink repair, focusing on both the classical Fanconi anemia pathway and newly discovered pathways. It aims to understand the roles of specific proteins, chromatin dynamics, and the mutagenic effects of repair processes, ultimately enhancing knowledge of ge…
DNA interstrand crosslinks (ICLs) are toxic DNA lesions that are induced by cancer chemotherapeutics but are also formed endogenously. ICL repair is mostly linked to DNA replication, which complicated the biochemical dissection of this process.
The classical ICL repair pathway is the Fanconi anemia pathway, affected in the cancer predisposition syndrome Fanconi anemia (FA).
Although the repair mechanism is poorly understood, recent studies have revealed unanticipated insights that now allow us t…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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