CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of the XPF/ERCC1 protein complex in DNA repair mechanisms that contribute to platinum resistance in cancer cells. By combining structural and kinetic studies, the goal is to develop inhibitors that enhance the effectiveness of chemotherapy treatments.
Cancer chemotherapeutic drugs, such as platinum agents, work by producing DNA damage that causes cell-cycle arrest and cell death.
However, DNA repair pathways can enable tumour cells to survive DNA damage induced by chemotherapeutic treatments.
Platinum resistance is a major clinical problem in cancer treatment and there is a considerable interest in inhibitors of DNA repair pathways, that can increase efficiency of chemotherapy, when administered together.
An attractive target to circumvent pl…
Masarykova univerzita
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
