CORDIS Project
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This project explores the reactivation of the inactive X chromosome in female mice during germline development. By analyzing gene activity and chromatin changes at a single-cell level, it aims to uncover mechanisms of X chromosome reprogramming and its implications for inheritance.
In female mice, one of the two X chromosomes is inactivated during early development to ensure dosage compensation between genders. A long non-coding gene, Xist, plays a crucial role in the initiation of the X chromosome inactivation (XCI) process.
Primordial germ cells (PGCs), the precursors of sperm and eggs, transmit genetic and epigenetic information to subsequent generations, following extensive reprogramming, erasure of methylation and genomic imprints, and X chromosome reactivation.
The i…
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