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The XX-Health project investigates how genes that escape X-inactivation influence T-cell responses in females, aiming to understand sex differences in immune responses. It employs a novel method, TriX-Seq, to analyze X-inactivation patterns in T-cells from a large cohort of women, providing insights into autoimmune dis…
Females have a higher risk for autoimmune disease and lower risk of mortality from infectious disease than males, reflecting a more robust immune response in females against both self-antigens (autoimmunity) and non-self-antigens (infections).
Genes that escape the process of X-inactivation (XCI) are present in a higher dose in female cells and many play key roles in T-cell biology. XX-Health will reveal the role of escape genes in mediating sex-differences in T-cell response.
Different cells i…
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