CORDIS Project
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This project investigates the relationship between metabolic enzymes and gene regulation in yeast. It aims to identify RNA-binding proteins and their interactions with mRNAs, shedding light on how metabolism influences gene expression.
The interconnections between intermediary metabolism and regulation of gene expression are relatively poorly understood. A few reports have analysed the ability of some metabolic enzymes to 'moonlight' as RNA-binding proteins, being responsive to small metabolites that often represent co-factors of the enzymes.
Building on these observations, it was recently proposed that regulatory networks formed between mRNAs, Enzymes and Metabolites (REM networks) might represent a novel regulatory layer int…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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