CORDIS Project
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This project investigates the role of Z-DNA/RNA in immune responses, focusing on specific protein interactions. By identifying substrates for Zα domains, it aims to enhance understanding of viral recognition and develop small-molecule inhibitors for potential antiviral therapies.
DNA/RNA molecules adopting the Z-conformation have been known to possess immunogenic properties.
However, their biological role and importance has been a topic of debate for many years.
The discovery of Z-DNA/RNA binding domains (Zα domains) in varied proteins that are involved in the innate immune response, such as the interferon induced form of the RNA editing enzyme ADAR1 (p150), Z-DNA binding protein 1 (ZBP1), the fish kinase PKZ and the pox-virus inhibitor of interferon response E3L, indica…
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