CORDIS Project
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This project aims to explore the role of the ZEB1 protein in neural stem cell development and its implications for neurodevelopmental disorders. By using mouse models and genomic techniques, the research will provide insights into how ZEB1 regulates gene expression in neural cells.
Current interest in neural stem cells derives from the prospect of using them in brain repair strategies, but also to understand neurodevelopmental pathologies.
This will require, however, a significant improvement of our understanding of the gene expression programs associated with their maintenance and differentiation, and how these are regulated.
Recently, several lines of evidence suggest a regulatory function for the zinc-finger transcription factor ZEB1, both in embryonic neural stem/pro…
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