CORDIS Project
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This project aims to explore how mechanical forces influence heart valve development and regeneration. By studying endocardial cells in response to these forces, it seeks to uncover molecular programs essential for normal and pathological heart function.
Cardiovascular diseases (CVDs) take a huge toll on the world population.
An estimated 19 million people died from CVDs in 2010, representing 30% of all global deaths.
Abnormal blood circulation is widely recognized as a cardiovascular risk factor and mechanotransduction has been shown to trigger pathologies such as atherosclerosis1, cardiomyopathies2 and valvulopathies3.
Mechanotransduction is the conversion of a mechanical stimulus into a biological response.
It is central to the coordination b…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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