CORDIS Project
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This project investigates the role of Wnt signaling in the formation of somites during embryonic development in zebrafish. By using advanced genetic techniques and imaging, it aims to understand how Wnt interacts with other pathways to regulate the segmentation process essential for vertebrate body structure.
Segmental elements of the vertebrate body plan, such as vertebrae, ribs and most skeletal muscles, derive from embryonic somites.
Somitogenesis is a spatially periodic process that is prefigured in the presomitic mesoderm (PSM) by coordinated oscillations of gene expression that set the rhythm of the “segmentation clock”.
The position in the PSM where these oscillations arrest is termed the determination front and is the site where segment boundary is positioned.
Although the Delta/Notch pathway…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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