CORDIS Project
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This project investigates the role of primary cilia in heart development and disease, focusing on cardiac valves. Using advanced imaging techniques, it explores how the protein DZIP1 influences cilia dynamics and functions during the formation of heart structures, particularly in endocardial cells.
This project aims at revealing the function of primary cilia during cardiovascular development and cardiovascular diseases, with a specific focus on cardiac valves, through an imaging approach based on expansion light microscopy.
Cilia are evolutionary conserved organelles, involved in fundamental processes such as motility, signalling and mechano-sensing, associated with a group of developmental diseases termed ciliopathies.
Cardiovascular defects are common in patients diagnosed with ciliopath…
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