CORDIS Project
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This research focuses on understanding how transcription factors regulate gene expression during zygotic genome activation in fruit flies. It combines in vitro and in vivo studies to explore the interactions of the transcriptional activator Zelda with DNA and its role in gene regulation.
A long-standing question in biology is how do transcription activators and repressors exert their function over large batteries of specific targets spread throughout the genome in a timely and coordinated way.
An excellent model system to study this process is zygotic genome activation (ZGA) that happens during development of every animal and hallmarks initiation of transcription from the zygotic genome.
During ZGA, developmental cues such as morphogen gradients are converted into coordinated an…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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