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ZoomNMR aims to enhance NMR spectroscopy for studying small molecules within large biological complexes. By using innovative isotope labeling and relaxation techniques, it seeks to improve sensitivity and resolution, facilitating mechanistic studies and drug design.
Small molecules are critical players in the chemistry of life.
In the role of substrates, cofactors, solvent, inhibitors or activators, they steer the activities of proteins and nucleic acids.
For mechanistic studies, it would be desirable to single out a small ligand from a large macromolecular complex, even if their sizes lie several orders of magnitude apart, and follow its fate during chemical and structural transformations.
Few experimental techniques would achieve this under native conditi…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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