CORDIS Project
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This project investigates the role of non-coding regulatory elements in pancreatic diseases, particularly diabetes, using zebrafish as a model. By studying gene regulation and comparing it with human data, the project aims to identify new genetic factors associated with diabetes, potentially improving clinical manageme…
Several human pancreatic diseases have been characterized, being the diabetes the most common.
Like others, this genetic disease is related to disrupted non-coding cis-regulatory elements (CREs) that culminate in altered gene expression.
Although Genome Wide Association Studies support this hypothesis, it’s still unclear how mutations on CREs contribute to disease.
The translation from the “non-coding code” to phenotype is an exciting and unexplored field that we will approach in this project wi…
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