CORDIS Project
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The project aims to develop a custom DNA chip for analyzing 5-hydroxymethylcytosine, a potential cancer biomarker. By creating a cost-effective method for mapping this epigenetic marker, the project seeks to facilitate large-scale research and improve disease diagnostics.
5-hydroxymethylcytosine (5hmC) is an oxidized form of 5-methylcytosine (5mC).
It is the first step of reversing DNA methylation and an important indicator of dynamic epigenetic changes in genomic DNA.
One characteristic of cancerous transformations is dramatic modulation of the epigenomic landscape.
Consequently, changes in the distribution of 5hmC have been shown to correlate with a broad range of cancers and is potentially a powerful disease biomarker.
Nevertheless, existing methods for mappin…
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