CORDIS Project
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This project focuses on enhancing the use of methyltransferase enzymes for selective methylation in biological systems. By developing cost-effective methods for producing synthetic cofactors, it aims to improve the availability of these reagents for research and clinical applications, ultimately facilitating advancemen…
Enzymatic addition of a methyl group (methylation) is the most prevalent natural modification in cells, serving a myriad of regulatory and structural functions.
Abnormal methylation of DNA, RNA or histone proteins can lead to severe developmental defects and is associated with numerous human diseases.
Selective methylation of biomolecular targets is carried out by dedicated methyltransferase enzymes, which use the cofactor S-adenosyl-L-methionine (AdoMet) as the source of methyl groups.
Despite…
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