CORDIS Project
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This project addresses drug-resistant epilepsy caused by cortical malformations, proposing a pharmacological strategy to eliminate mutated cells using existing drugs. It aims to provide new precision therapies for children suffering from this debilitating condition.
Epilepsy is a frequent neurological disorder characterized by recurrent seizures resulting from hyperexcitability and hypersynchrony of neuronal networks.
Cortical malformations, including Focal Cortical Dysplasia (FCD), are rare sporadic diseases that cause early-life drug-resistant seizures for which surgery is the only therapeutic option to control seizures.
Surgical inaccessibility and failures are significant clinical drawbacks.
This emphasizes a critical and urgent need for new precision-b…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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