CORDIS Project
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This project focuses on developing broad-spectrum antiviral drugs targeting the S2 domain of coronaviruses to prevent future outbreaks. By screening over 173,000 compounds, it aims to identify effective small molecules that can inhibit viral infection and potentially be used as oral medications to reduce hospitalizatio…
The Covid-19 pandemic emphasized the urgent need for efficient broad-spectrum antiviral drugs against potential future coronaviruses (CoV) strains that may cause the next COVID pandemic. A critical stage during infection is the fusion of the viral envelope with the host-cell membrane, which depends on the conserved S2 domain of the viral Spike (S) protein.
Hence, targeting the S2 domain is a promising approach to achieving pan-CoV inhibition.
Since MERS- and SARS- S proteins bind to different ce…
WEIZMANN INSTITUTE OF SCIENCE
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