CORDIS Project
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This project investigates the role of mechanical signals in cancer progression by targeting a specific protein interaction involved in mechanotransduction. By inhibiting the stiffness-induced unfolding of this protein, the project aims to develop novel therapeutic agents for treating solid tumors, particularly breast a…
Increased tissue stiffness is a hallmark of many solid tumours, driving tumour progression.
This occurs through mechanotransduction, the process by which cells sense and respond to mechanical signals.
Our lab has identified a key interaction between two proteins, essential for mechanotransduction.
This interaction is triggered by force-induced unfolding of a target protein, which occurs only in stiff tissues.
Hence, we propose a novel therapeutic approach that targets mechanotransduction by inhi…
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
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