CORDIS Project
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This project seeks to develop a targeted drug delivery system for treating non-alcoholic fatty liver disease using cannabinoid receptor blockers. The innovative approach aims to minimize side effects while effectively addressing obesity-related liver conditions.
Obesity is a catalyst for numerous conditions; the most notable is non-alcoholic fatty liver disease (NAFLD), for which currently no drug therapy has been approved by the FDA and EMA for its treatment.
The endocannabinoid (eCB) system triggers the development of obesity and its related comorbidities, specifically NAFLD. eCBs, via activating the cannabinoid-1 receptors (CB1Rs) in the liver, increase hepatic glucose production, insulin resistance, and de novo lipogenesis, and decrease fatty acid o…
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